Molecular Aspects and Health Issues
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The presence of carotenoids in the diet and their role in human health has become a subject of unprecedented interest. A roundtable discussion on the Safety of ß-Carotene and a workshop on Carotenoids and Retinoids: Molecular Aspects and Health Issues were held at the annual Oxygen Club of California (OCC) conference in Santa Barbara, California, on March 10-13, 2004. The chapters in this book represent an account of the information presented at the workshop, combined with several additional invited contributions to cover topics more completely that are currently at the cutting edge of research. Some of the highlights of this book include a thorough review of the special role that vitamin A intake plays in the health status of developing countries, the essential role of vitamin A in cell signaling, the molecular targets involved in carotenoid action in smoke-induced lung pathology, and how carotenoids are beneficial in cardiovascular health.
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| Released: 05/01/2005; 364 pages | |||||||||||||
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1. Introduction to Retinoids
2. Introduction to Vitamin A: A Nutritional and Life Cycle Perspective
3. The Essential Role of Vitamin A in Signal Transduction
4. Chemical and Metabolic Oxidation of Carotenoids
5. Gap Junctional Intercellular Communication: Carotenoids and Retinoids
6. Raman Detection of Carotenoids in Human Tissue
7. Macular Carotenoids in Eye Health
8. b-Carotene Cleavage Products Impair Cellular and Mitochondrial Functions and May Lead to Genotoxicity
9. Formation of b-Carotene Cleavage Products in View of the Particular Conditions in Inflamed Lung Tissue
10. Biological Activity of Lycopene Against Smoke-Induced Lung Lesions: Targeting IGF-1/IGFBP-3 Signal Transduction Pathway
11. Retinoids and Carotenoids as Cancer Chemopreventive Agents: Role of Upregulated Gap Junctional Communication
12. Lycopene and Risk of Cardiovascular Disease
13. Effect of Feeding and Then Depleting a High Fruit and Vegetable Diet on Oxidizability in Human Serum
14. Mitochondria as Novel Targets for Proapoptotic Synthetic Retinoids
15. Molecular Analysis of the Vitamin A Biosynthetic Pathway
16. Regulation of Transcription by Antioxidant Carotenoids
17. Vitamin A in Health and Disease in Developing Countries
18. Lycopene and Prostate Cancer
19. Blood Response to b-Carotene Supplementation in Humans: An Evaluation Across Published Studies
20. New Horizons in Carotenoid Research
21. Carotenoids and Cardiovascular Disease
22. Safety of b-Carotene
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